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Innovation & Growth Initiative: Montgomery County Benchmark
Learn about Abington's Next Century. To access a white paper that compares Abington to the rest of Montgomery County, click here >
Science Daily - Kidney News
Medical research on the kidney, causes and symptoms of kidney infections and failure. Find out about green tea and other food that affects the kidneys. Read about kidney stones and other kidney problems.
Updated: 34 weeks 6 days ago
Patients with uncontrolled high blood pressure treated with renal denervation had low rates of adverse events and significant lowering of blood pressure at six months, according to a registry-based study.
Diabetics with major depressive symptoms had an 85% higher risk of developing kidney failure, results of a new study have concluded. Minor depressive symptoms were not significantly linked with the development of kidney failure among diabetics overall.
A receptor called B7-1 is expressed by kidney cells during the progression of kidney disease in diabetic mice and humans. Targeting this receptor with an available drug called CTLA4-Ig, or abatacept, helps to maintain kidney function in mice, research concludes. "The next steps will be to test anti-B7-1 drugs in individuals with diabetes and diabetic nephropathy to see if they can abrogate the progression of the disease in humans as well," said a lead author.
The decision to initiate dialysis for acute kidney injury varies depending on different patient factors and there is a lack of robust evidence as to which patients are likely to benefit most and why. A new study has shown that for patients with lower creatinine concentration levels -- a sign of reduced muscle mass and weakness -- initiation of dialysis could actually be detrimental.
Men who, as children, had glomerular disease, a disorder of the portion of the kidney that filters blood and one that usually resolves with time, were more likely than men without childhood glomerular disease to have high blood pressure as an adult, according to a study.
Engineers have reversed a decades-long trend of decreasing efficiency in lithotripsy machines by designing simple modifications to shock wave lenses. The incidence of kidney stones in the United States has more than doubled during the past two decades, due at least in part to the expanding waistlines of its citizens. The condition has also been linked to hot, humid climates and high levels of stress -- a combination of living environments that seems to have led to a rise in kidney stone rates of veterans returning home from Iraq and Afghanistan.
In a new study, it was observed that in rats with kidney disease, functioning of the kidney improved when the organ was fused with the omentum, a fatty fold of tissue that lies close to the kidney and is a rich source of stem cells. The findings suggest that stem cells from a chronic kidney disease patient’s own omentum may help heal diseased kidneys without the need for an outside source of cells.
A natural product found in grapefruit can prevent kidney cysts from forming, new research indicates. Naringenin, which is also present in other citrus fruits, has been found to successfully block the formation of kidney cysts, an effect that occurs in polycystic kidney disease, by regulating the PKD2 protein responsible for the condition. With few treatments currently available, symptoms include high blood pressure and loss of kidney function, and lead to the need for dialysis.
A new urine test can distinguish among different causes of kidney dysfunction in kidney transplant recipients. Still under development, if it is validated in a larger multicenter study, the test may allow patients to avoid invasive kidney biopsies. "Our study shows that when the creatinine level is elevated in the blood of a kidney transplant recipient, use of our urine test would differentiate the common causes of kidney dysfunction that led to the elevation in creatinine, hence benefiting many patients by allowing them to avoid the need for an invasive needle biopsy," said the lead researcher.
A simple way to treat kidney failure. A new technique for purifying blood using a nanofiber mesh could prove useful as a cheap, wearable alternative to kidney dialysis.
Although some research has suggested that the use of the anticoagulant warfarin for atrial fibrillation among patients with chronic kidney disease would increase the risk of death or stroke, a study that included more than 24,000 patients found a lower one-year risk of the combined outcomes of death, heart attack or stroke without a higher risk of bleeding.
Two new markers for acute kidney injury have been determined, thanks to new research. Acute kidney injury (AKI) has been difficult to diagnose and treat early because current markers for it don't show up until several hours after it has begun. The research group, however, validated two new markers -- tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) -- in urine that, when assessed together, give clinicians the ability to detect and begin treating AKI much earlier than the current standards.
Prevention and reversal of chronic kidney disease is an urgent public health need. The disease affects 1 in 10 Americans, is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure. New research has uncovered abnormal molecular signaling pathways from disease initiation to irreversible kidney damage, kidney failure, and death.
Biopsy-detected injury in donated kidneys was modestly associated with a delay in organ function in the first week after transplantation, but only for donor kidneys already known to be at high risk. Donor kidney biopsies frequently underreported kidney injury with substantial variability. The study also showed that there was a large degree of overlap between the results of biopsies from kidneys that were deemed unsuitable for transplantation and kidneys that were approved for transplantation. The quality of biopsies used in acceptance decisions was low.
In a study of 267 patients with chronic kidney disease, 69% of participants experienced at least one hazardous event related to their outpatient care. Hypoglycemia (in patients with diabetes) and falling or severe dizziness (in patients without diabetes) were most frequently paired with other complications of medical care. "Disease-specific adverse safety event events are strikingly common in CKD," concludes the lead author.
Researchers say the discovery of how sodium ions pass through the gill of a zebrafish may be a clue to understanding a key function in the human kidney. In this research, the protein allows the sodium ions to be absorbed from the forming urine while at the same time discarding waste from normally functioning cells, thus keeping the body in balance and serving as an energy saving system. The researchers say the same NHE3 protein performs a similar function in the intestine, pancreas, liver, lungs and reproductive system.
A vaccine-based clinical trial is underway, aimed at providing kidney cancer patients long-term control of their disease. Survival outcomes for patients with renal cell carcinoma, the most common form of kidney cancer, have improved significantly over the past decade due to research advances in personalized or "targeted" therapies designed to target an individual's genetic makeup. To expedite these benefits, investigators are now looking to couple targeted therapies with vaccine-based approaches, which use a patient's own immune system to fight disease and may have the potential to improve survival outcomes and overall quality of life.
A team of researchers has found that kidney cancer cells have a quite different metabolism than other types of malignancies. The findings pave the way for new methods of diagnosing kidney cancer at an early stage, a feat that had eluded researchers earlier, and thereby fresh approaches to treatment. "Because kidney cancer cells metabolize abnormally, they have to fight for their survival," says the scientist who constructed the cell models. "As a result, it should be possible to customize a way of taking advantage of their vulnerabilities so as to kill them without damaging healthy cells."
Nearly 5,000 people die each year in the US waiting for a kidney transplant. A researcher has now developed a mathematical model that simulates and optimizes donor kidney distribution. The model identifies areas for policy changes, including encouraging more sharing within states. The innovative model could help ease inequities among regions in the US and ultimately help save hundreds of lives.
For pregnant women with kidney failure who underwent dialysis for more than 36 hours per week, the live birth rate was 85%, while it was only 48% in women dialyzed for 20 hours or less per week. Infants were a healthier weight at birth when women were dialyzed for more than 20 hours per week than when women were dialyzed for 20 hours or less per week. Pregnancy complications were few and manageable in patients receiving intensive dialysis.